Publications of the Week A Phase I/II Trial Combining Avelumab and Trabectedin for Advanced Liposarcoma and LeiomyosarcomaWagner, M. J., et al. | April 4, 2022Leiomyosarcoma (LMS) and liposarcoma (LPS) frequently express PD-L1 but are generally resistant to PD-1/PD-L1 inhibition…dcorriganApril 4, 2022 Read More
Publications of the Week Effect of Lung Pericyte-Like Cell Ablation on the Bleomycin Model of Injury and RepairHung, C., et al. | March 31, 2022The authors have previously showed that pericyte-like cells derived from the FoxD1-lineage contribute to myofibroblasts…dcorriganMarch 31, 2022 Read More
Publications of the Week dCas9 Fusion to Computer-Designed PRC2 Inhibitor Reveals Functional TATA Box in Distal Promoter RegionLevy, S., et al. | March 30, 2022Bifurcation of cellular fates, a critical process in development, requires histone 3 lysine 27 methylation…dcorriganMarch 30, 2022 Read More
Publications of the Week Oral Desensitization Therapy for Peanut Allergy Induces Dynamic Changes in Peanut-Specific Immune ResponsesBajzik, V., et al. | March 25, 2022The authors defined key mechanistic correlates of the reduction of clinical reactivity to peanuts observed…dcorriganMarch 25, 2022 Read More
Publications of the Week The Endophilin Curvature-Sensitive Motif Requires Electrostatic Guidance to Recycle Synaptic Vesicles In VivoZhang, L., et al. | March 24, 2022Curvature-sensing mechanisms assist proteins in executing particular actions on various membrane organelles. Here, we investigate…dcorriganMarch 24, 2022 Read More
Publications of the Week Lamin B1 Deletion in Myeloid Neoplasms Causes Nuclear Anomaly and Altered Hematopoietic Stem Cell FunctionReilly, A., et al. | March 22, 2022Abnormal nuclear morphology is a hallmark of most cancers, widely used in cancer diagnosis. In…dcorriganMarch 22, 2022 Read More
Publications of the Week The Alzheimer’s Gene SORL1 Is a Regulator of Endosomal Traffic and Recycling in Human NeuronsMishra, S., et al. | March 16, 2022In this work, we continued our studies on the gene SORL1, which is emerging as…dcorriganMarch 16, 2022 Read More
Publications of the Week Mechanical Forces Govern Interactions of Host Cells with Intracellular Bacterial PathogensBastounis, E. E., et al. | March 16, 2022To combat infectious diseases, it is important to understand how host cells interact with bacterial…dcorriganMarch 16, 2022 Read More
Publications of the Week REL and BHLHE40 Variants Are Associated with IL-12 and IL-10 Responses and Tuberculosis RiskJournal of Immunology | March 11, 2022The major human genes regulating Mycobacterium tuberculosis–induced immune responses and tuberculosis (TB) susceptibility are poorly understood.…dcorriganMarch 11, 2022 Read More
Publications of the Week Global and Context-Specific Transcriptional Consequences of Oncogenic Fbw7 MutationsNayanga Thirmanne, H., et al. | March 9, 2022The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors…dcorriganMarch 9, 2022 Read More