Publications of the Week Integrated Analysis of Cross-Links and Dead-End Peptides for Enhanced Interpretation of Quantitative XL-MS Keller, Andrew, et al. | August 16, 2023 Chemical cross-linking with mass spectrometry provides low-resolution structural information on proteins in cells and tissues.…sciencecityAugust 16, 2023 Read More
Publications of the Week Familial Co-segregation and the Emerging Role of Long-Read Sequencing to Re-Classify Variants of Uncertain Significance in Inherited Retinal Diseases Gupta, P., et al. | August 15, 2023 Phasing genetic variants is essential in determining those that are potentially disease-causing. In autosomal recessive…pthomsonAugust 15, 2023 Read More
Publications of the Week Peripheral Macrophages Drive CNS Disease in the Ndufs4(−/−) Model of Leigh Syndrome Hanaford, Allison R., et al. | August 14, 2023 Subacute necrotizing encephalopathy, or Leigh syndrome (LS), is the most common pediatric presentation of genetic…sciencecityAugust 14, 2023 Read More
Publications of the Week Observing Inhibition of the SARS-CoV-2 Helicase at Single-Nucleotide Resolution Laszlo, A., et al. | August 11, 2023 The genome of SARS-CoV-2 encodes for a helicase (nsp13) that is essential for viral replication…pthomsonAugust 11, 2023 Read More
Publications of the Week Proteogenomic Analysis of Chemo-Refractory High-Grade Serous Ovarian Cancer Paulovich, A., et al. | August 7, 2023 To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), scientists characterized the proteogenomic…pthomsonAugust 7, 2023 Read More
Publications of the Week Donor T Cell STAT3 Deficiency Enables Tissue PD-L1–Dependent Prevention of Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Activity Li, Q., et al. | August 3, 2023 STAT3 deficiency (STAT3–/–) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on…pthomsonAugust 3, 2023 Read More
Publications of the Week Multi-Level Functional Genomics Reveals Molecular and Cellular Oncogenicity of Patient-Based 3′ Untranslated Region Mutations Hsieh, A., et al. | July 31, 2023 3′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic…pthomsonJuly 31, 2023 Read More
Publications of the Week Intestinal Microbiota Controls Graft-Versus-Host Disease Independent of Donor-Host Genetic Disparity Hill, G., et al. | July 27, 2023 Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic stem cell transplantation (SCT), and…pthomsonJuly 27, 2023 Read More
Publications of the Week Hypoxia-Induced Mitochondrial Stress Granules Crowder, C. M., et al. | July 21, 2023 Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic…pthomsonJuly 21, 2023 Read More
Publications of the Week Factors Associated with Recurrent Appendicitis After Successful Treatment with Antibiotics Flum, D., et al. | July 19, 2023 As more patients with appendicitis are treated with antibiotics, factors associated with recurrence may help…pthomsonJuly 19, 2023 Read More