Publications of the Week De Novo Design of Protein Structure and Function with RFdiffusion Baker, D., et al. | July 14, 2023 The authors showed that by fine tuning the RoseTTAFold structure prediction network on protein structure…pthomsonJuly 14, 2023 Read More
Publications of the Week A Human-Specific Motif Facilitates CARD8 Inflammasome Activation After HIV-1 Infection Mitchell, P., et al. | July 12, 2023 Inflammasomes are cytosolic innate immune complexes that assemble upon detection of diverse pathogen-associated cues and…pthomsonJuly 12, 2023 Read More
Publications of the Week CD1 and iNKT Cells Mediate Immune Responses Against the GBS Hemolytic Lipid Toxin Induced by a Non-toxic Analog Rajagopal, L., et al. | July 6, 2023 Although hemolytic lipids have been discovered from many human pathogens including Group B Streptococcus (GBS),…pthomsonJuly 6, 2023 Read More
Publications of the Week Androgen-Regulated Stromal Complement Component 7 (C7) Suppresses Prostate Cancer Growth Xin, L., et al. | July 5, 2023 Investigators show that C7 is specifically expressed by the stromal cells in both mouse and human…pthomsonJuly 5, 2023 Read More
Publications of the Week Nuclear Pore Complexes Mediate Subtelomeric Gene Silencing by Regulating PCNA Levels on Chromatin Aitchison, J. D., et al. | June 30, 2023 The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The Saccharomyces cerevisiae…pthomsonJune 30, 2023 Read More
Publications of the Week A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells Zernicka-Goetz, M., et al. | June 30, 2023 Stem cell-derived models of the embryo are important tools to interrogate developmental events and tissue-tissue…pthomsonJune 30, 2023 Read More
Publications of the Week Role of Mitochondria in the Myopathy of Juvenile Dermatomyositis and Implications for Skeletal Muscle Calcinosis Lood, C., et al. | June 27, 2023 Patients with JDM exhibited elevated levels of mitochondrial markers associated with muscle damage and calcinosis.…pthomsonJune 27, 2023 Read More
Publications of the Week Minimizing the Off-Target Frequency of the CRISPR/Cas9 System via Zwitterionic Polymer Conjugation and Peptide Fusion† Han, Y. et al. | June 22, 2023 The clustered, regularly interspaced, short palindromic repeats (CRISPR)–associated protein 9 (Cas9) system is a powerful…pthomsonJune 22, 2023 Read More
Publications of the Week The Unfolded Protein Response Components IRE1α and XBP1 Promote Human Coronavirus Infection Fink, S. L., et al. | June 13, 2023 The cellular processes that support human coronavirus replication and contribute to the pathogenesis of severe…pthomsonJune 13, 2023 Read More
Publications of the Week Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid Hoofnagle, A. N., et al. | June 13, 2023 APOE genotype is associated with Alzheimer's disease. Thus, the concentration of apolipoprotein E (apoE) isoforms…pthomsonJune 13, 2023 Read More