Publications of the Week

SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here we examine whether…

General approaches for designing sequence-specific peptide-binding proteins would have wide utility in proteomics and synthetic…

There are many open questions about the mechanisms that coordinate the dynamic, multicellular behaviors required…

Gain-of-function mutations in voltage-gated sodium channel NaV1.7 cause severe inherited pain syndromes, including inherited erythromelalgia…

The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells…

 Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects…

 B cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus…

Adeno-associated viruses (AAVs) are being developed as gene therapy vectors due to their low pathogenicity…

Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of…

CRISPR-Cas9 has yielded a plethora of effectors, including targeted transcriptional activators, base editors and prime…