Publications of the Week EXT418, a Novel Long-Acting Ghrelin, Mitigates Lewis Lung Carcinoma Induced Cachexia in Mice Kerr, H.L., et al. | March 28, 2023 Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects…sciencecityMarch 28, 2023 Read More
Publications of the Week B Cell-Activating Factor (BAFF) From Dendritic Cells, Monocytes and Neutrophils Is Required for B Cell Maturation and Autoantibody Production in SLE-like Autoimmune Disease Giordano, D., et al. | March 22, 2023 B cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus…sciencecityMarch 22, 2023 Read More
Publications of the Week A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins Porter, J.M., et al. | March 20, 2023 Adeno-associated viruses (AAVs) are being developed as gene therapy vectors due to their low pathogenicity…sciencecityMarch 20, 2023 Read More
Publications of the Week Improving the Secretion of Designed Protein Assemblies Through Negative Design of Cryptic Transmembrane Domains Wang, J.Y.J., et al. | March 15, 2023 Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of…sciencecityMarch 15, 2023 Read More
Publications of the Week A Chemically Controlled Cas9 Switch Enables Temporal Modulation of Diverse Effectors Wei, C.T., et al. | March 14, 2023 CRISPR-Cas9 has yielded a plethora of effectors, including targeted transcriptional activators, base editors and prime…sciencecityMarch 14, 2023 Read More
Publications of the Week Linking Connectome with Transcriptome Using a Self-Inactivating Rabies Virus Yao, S. and Levi, B.P. | March 8, 2023 Genetically engineered rabies virus is a powerful tool for investigating the structure and function of…sciencecityMarch 8, 2023 Read More
Publications of the Week Automatic and Accurate Ligand Structure Determination Guided by Cryo-Electron Microscopy Maps Muenks, A., et al. | March 6, 2023 Advances in cryo-electron microscopy (cryoEM) and deep-learning guided protein structure prediction have expedited structural studies…sciencecityMarch 6, 2023 Read More
Publications of the Week Reversible Epigenetic Alterations Mediate PSMA Expression Heterogeneity in Advanced Metastatic Prostate Cancer Sayer, E., et al. | March 1, 2023 Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate cancer. There are…pthomsonMarch 1, 2023 Read More
Publications of the Week MUC5AC Genetic Variation Is Associated with Tuberculous Meningitis CSF Cytokine Responses and Mortality Sabo, M. C., et al. | February 28, 2023 Independent SNPs in MUC5B and MUC5AC (genotyped by Illumina HumanOmniExpress array) were assessed for associations with TNF concentrations (measured…pthomsonFebruary 28, 2023 Read More
Publications of the Week ATP Is a Major Determinant of Phototrophic Bacterial Longevity in Growth Arrest Yin, L., et al. | February 22, 2023 How bacteria transition into growth arrest as part of stationary phase has been well-studied, but…sciencecityFebruary 22, 2023 Read More