Publications of the Week TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis Venkatasubramanian, S., et al. | July 19, 2022 The authors found that TOLLIP, a gene associated with TB susceptibility, influences dendritic cell maturation,…dcorriganJuly 19, 2022 Read More
Publications of the Week A Slow Dynamic RNA Switch Regulates Processing of microRNA-21 Shortridge, M. D., et al. | July 15, 2022 The microRNAs are non-coding RNAs which post-transcriptionally regulate the expression of many eukaryotic genes, and whose dysregulation…dcorriganJuly 15, 2022 Read More
Publications of the Week Analysis of the HVTN 702 Phase 2b-3 HIV-1 Vaccine Trial in South Africa Assessing RV144 Antibody and T Cell Correlates of HIV-1 Acquisition Risk Moodie, Z., et al. | July 14, 2022 Read the Publication This week we profile a recent publication in The Journal of Infectious…dcorriganJuly 14, 2022 Read More
Publications of the Week Development of a Primary Human Intestinal Epithelium Enriched in L-Cells for Assay of GLP-1 Secretion Villegas-Novoa, C., et al. | July 8, 2022 Type 2 diabetes mellitus is a chronic disease associated with obesity and dysregulated human feeding…dcorriganJuly 8, 2022 Read More
Publications of the Week Mapping Functional Regions of Essential Bacterial Proteins with Dominant-Negative Protein Fragments Savinov, A., Fernandez, A., and Fields, S. | July 7, 2022 Peptide fragments can inhibit the interactions of the full-length proteins from which the fragments derive. The…dcorriganJuly 7, 2022 Read More
Publications of the Week Guselkumab Provides Sustained Domain-Specific and Comprehensive Efficacy Using Composite Indices in Patients with Active Psoriatic Arthritis Coates, L. C., et al. | July 1, 2022 The authors evaluate the efficacy of guselkumab for the treatment of active psoriatic arthritis (PsA)…dcorriganJuly 1, 2022 Read More
Publications of the Week Shifting Mutational Constraints in the SARS-CoV-2 Receptor-Binding Domain during Viral Evolution Science | June 29, 2022 SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its…dcorriganJune 29, 2022 Read More
Publications of the Week Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis Njikan, S., et al. | June 23, 2022 The authors previously identified a phenylthiourea series with activity against intracellular Mycobacterium tuberculosis using a high-throughput,…dcorriganJune 23, 2022 Read More
Publications of the Week Blockade of Interleukin 10 Potentiates Antitumor Immune Function in Human Colorectal Cancer Liver Metastases Sullivan, K. M., et al. | June 21, 2022 The authors' central goal is to address is how the immunosuppressive microenvironment created by solid…dcorriganJune 21, 2022 Read More
Publications of the Week Succinate Metabolism in the Retinal Pigment Epithelium Uncouples Respiration from ATP Synthesis Hass, D. T., et al. | June 17, 2022 Fumarate can be a surrogate for O2 as a terminal electron acceptor in the electron transport…dcorriganJune 17, 2022 Read More