Publications of the Week Brain Capillary Pericytes Exert a Substantial but Slow Influence on Blood Flow Hartmann, D.A., et al. | February 26, 2021 The research in our lab focuses on the smallest blood vessels that deliver oxygen and…kchenFebruary 26, 2021 Read More
Publications of the Week The Krüppel-Like Factor Cabut Has Cell Cycle Regulatory Properties Similar to E2F1 Zhang, P., et al. | February 24, 2021 Using a gain-of-function screen in Drosophila, we identified the Krüppel-like factor Cabut (Cbt) as a…kchenFebruary 24, 2021 Read More
Publications of the Week Targeting the Membrane-Proximal C2-Set Domain of CD33 for Improved CD33-Directed Immunotherapy Godwin, C.D., et al. | February 22, 2021 There is increasing interest in targeting CD33 in malignant and non-malignant disorders. In acute myeloid…kchenFebruary 22, 2021 Read More
Publications of the Week BRCA1/BARD1 Site-Specific Ubiquitylation of Nucleosomal H2A Is Directed by BARD1 Witus, S.R., et al. | February 19, 2021 Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to breast and…kchenFebruary 19, 2021 Read More
Publications of the Week A Curious Case for Development of Kinase Inhibitors as Antigiardiasis Treatments Using Advanced Drug Techniques Michaels, S. A., et al. | February 19, 2021 In this manuscript we discuss emerging drug development tools that can be used to accelerate…emcguinnFebruary 19, 2021 Read More
Publications of the Week T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination Layton, E. D., et al. | February 18, 2021 Peptide antigens are typically presented to T cells by highly polymorphic major histocompatibility complex (MHC)…emcguinnFebruary 18, 2021 Read More
Publications of the Week Residual β Cell Function in Long-Term Type 1 Diabetes Associates with Reduced Incidence of Hypoglycemia Gubitosi-Klug, R., et al. | February 12, 2021 We investigated residual β cell function in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions…emcguinnFebruary 12, 2021 Read More
Publications of the Week Conformation-Dependent Blockage of Activated VWF Improves Outcomes of Traumatic Brain Injury in Mice Xu, X., et al. | February 9, 2021 Traumatic brain injury-induced coagulopathy (TBI-IC) causes life-threatening secondary intracranial bleeding. Its pathogenesis differs mechanistically from…emcguinnFebruary 9, 2021 Read More
Publications of the Week Rapid Adaptation to Human Protein Kinase R by a Unique Genomic Rearrangement in Rhesus Cytomegalovirus Child, S., et al. | February 4, 2021 Cytomegaloviruses (CMVs) are generally unable to cross species barriers, in part because prolonged coevolution with…emcguinnFebruary 4, 2021 Read More
Publications of the Week Pleiotropic Mutations Can Rapidly Evolve to Directly Benefit Self and Cooperative Partner Despite Unfavorable Conditions Hart, S., et al. | February 2, 2021 Cooperation, paying a cost to benefit others, is widespread. Cooperation can be promoted by pleiotropic…emcguinnFebruary 2, 2021 Read More