Publications of the Week An Actin-Related Protein That Is Most Highly Expressed in Drosophila Testes Is Critical for Embryonic Development Schroeder, C., et al. | July 28, 2021 Most actin-related proteins (Arps) are highly conserved and carry out well-defined cellular functions in eukaryotes.…kchenJuly 28, 2021 Read More
Publications of the Week PGD2 and CRTH2 Counteract Type 2 Cytokine–Elicited Intestinal Epithelial Responses during Helminth Infection Oyesola, E., et al. | July 27, 2021 Type 2 inflammation is associated with epithelial cell responses, including goblet cell hyperplasia, that promote…kchenJuly 27, 2021 Read More
Publications of the Week The Interplay between Matrix Deformation and the Coordination of Turning Events Governs Directed Neutrophil Migration in 3D Matrices François, J., et al. | July 23, 2021 Neutrophils migrating through extravascular spaces must negotiate narrow matrix pores without losing directional movement. We…kchenJuly 23, 2021 Read More
Publications of the Week Accurate Prediction of Protein Structures and Interactions Using a Three-Track Neural Network Baek, M., et al. | July 22, 2021 DeepMind presented remarkably accurate predictions at the recent CASP14 protein structure prediction assessment conference. We…kchenJuly 22, 2021 Read More
Publications of the Week Multiplexed Functional Genomic Analysis of 5′ Untranslated Region Mutations across the Spectrum of Prostate Cancer Lim, Y., et al. | July 14, 2021 The functional consequences of genetic variants within 5’ untranslated regions (UTRs) on a genome-wide scale…kchenJuly 14, 2021 Read More
Publications of the Week SARS-CoV-2 Immune Evasion by the B.1.427/B.1.429 Variant of Concern McCallum, M., et al. | July 12, 2021 A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike…kchenJuly 12, 2021 Read More
Publications of the Week Activated Interleukin-7 Receptor Signaling Drives B-Cell Acute Lymphoblastic Leukemia in Mice Thomas, K. R., et al. | July 7, 2021 One key focus within our lab is to better understand signaling events that alter lymphocyte…kchenJuly 7, 2021 Read More
Publications of the Week Resolution of Tissue Signatures of Therapy Response in Patients with Recurrent GBM Treated with Neoadjuvant Anti-PD1 Lu, Y., et al. | July 6, 2021 The response of patients with recurrent glioblastoma multiforme to neoadjuvant immune checkpoint blockade has been…kchenJuly 6, 2021 Read More
Publications of the Week Pharmacologic Modulation of RNA Splicing Enhances Anti-Tumor Immunity Lu, S. X., et al. | July 5, 2021 Although mutations in DNA are the best-studied source of neoantigens that determine response to immune…kchenJuly 5, 2021 Read More
Publications of the Week Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury dos Santos, C. C., et al. | June 29, 2021 Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced lung injury in pre-clinical models, the…kchenJune 29, 2021 Read More