Publications of the Week Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure Tian, R., et al. | August 18, 2020 While mitochondria play an important role in innate immunity, the relationship between mitochondrial dysfunction and…emcguinnAugust 18, 2020 Read More
Publications of the Week When the Damage Is Done: Injury and Repair in Thymus Function Kinsella, S. and Dudakov, J. | August 13, 2020 Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or common…emcguinnAugust 13, 2020 Read More
Publications of the Week Low Concentration Il-1β Promotes Islet Amyloid Formation by Increasing hIAPP Release from Humanised Mouse Islets In Vitro Templin, A.T., et al. | August 5, 2020 Aggregation of the beta cell secretory product human islet amyloid polypeptide (hIAPP) results in islet…eabramovichAugust 5, 2020 Read More
Publications of the Week Structure-Guided Covalent Stabilization of Coronavirus Spike Glycoprotein Trimers in the Closed Conformation McCallum, M., et al. | August 5, 2020 SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than…eabramovichAugust 5, 2020 Read More
Publications of the Week Engineering Heart Morphogenesis Mandrycky, C., et al. | August 3, 2020 There is high potential for current technologies to be used to recapitulate heart development in vitro by…emcguinnAugust 3, 2020 Read More
Publications of the Week Increasing Fatty Acid Oxidation Prevents High Fat Diet Induced Cardiomyopathy through Regulating Parkin Mediated Mitophagy Shao, D., et al. | July 31, 2020 The Tian Laboratory focuses on the roles of cell metabolism and mitochondrial function in the pathogenesis of…emcguinnJuly 31, 2020 Read More
Publications of the Week The NK Cell–Cancer Cycle: Advances and New Challenges in NK Cell–Based Immunotherapies Bald, T., et al. | July 30, 2020 Natural killer (NK) cells belong to the innate immune system and contribute to protecting the…emcguinnJuly 30, 2020 Read More
Publications of the Week Assembly of the Threespine Stickleback Y Chromosome Reveals Convergent Signatures of Sex Chromosome Evolution Peichel, C., et al. | July 24, 2020 Heteromorphic sex chromosomes have evolved repeatedly across diverse species. Suppression of recombination between X and…emcguinnJuly 24, 2020 Read More
Publications of the Week Robust Expansion of HIV CAR T Cells following Antigen Boosting in ART-Suppressed Nonhuman Primates Rust, B., et al. | July 22, 2020 The authors observed that virus-specific CAR T-cells were less functional in vivo, relative to CAR T-cells…emcguinnJuly 22, 2020 Read More
Publications of the Week Small-Molecule Sensitization of RecBCD Helicase–Nuclease to a Chi Hotspot-Activated State Karabulut, A., et al. | July 17, 2020 We study a small molecule (NSAC1003) that one of our collaborators (Ryan Cirz) at Achaogen,…emcguinnJuly 17, 2020 Read More