Publications of the Week Spatial Modeling of Prostate Cancer Metabolic Gene Expression Reveals Extensive Heterogeneity and Selective VulnerabilitiesWang, Y., et al. | March 10, 2020Targeting metabolic aberrations has been a major focus in cancer research, and genome-scale metabolic network…sciencecityMarch 10, 2020 Read More
Publications of the Week The CD33 Splice Isoform Lacking Exon 2 as Therapeutic Target in Human Acute Myeloid LeukemiaGodwin, C.D., et al. | March 6, 2020Data from several randomized studies have shown that a CD33 antibody-drug conjugate reduces relapse risks…sciencecityMarch 6, 2020 Read More
Publications of the Week Increased Islet Antigen–Specific Regulatory and Effector CD4+ T Cells in Healthy Individuals with the Type 1 Diabetes–Protective HaplotypeWen, X., et al. | March 3, 2020Polymorphic histocompatibility genes in the HLA locus have a strong influence on genetic susceptibility to…sciencecityMarch 3, 2020 Read More
Publications of the Week STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural Regeneration from Muller Glia in Adult Mouse RetinaJorstad, N.L., et al. | February 27, 2020Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that…sciencecityFebruary 27, 2020 Read More
Publications of the Week Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer DriversYing, Z., & Beronja, S., | February 24, 2020Identification of clinically relevant drivers of breast cancers in intact mammary epithelium is critical for…sciencecityFebruary 24, 2020 Read More
Publications of the Week Connect-Seq to Superimpose Molecular on Anatomical Neural Circuit MapsHanchate, N.K., et al. | February 21, 2020Single-cell transcriptomics has emerged as a powerful means to define the molecular heterogeneity of brain…sciencecityFebruary 21, 2020 Read More
Publications of the Week Mechanisms of Endogenous HIV-1 Reactivation by Endocervical Epithelial CellsGornalusse, G.G., et al. | February 20, 2020The authors have demonstrated that the immunological activities of certain epithelial cells, in this case…sciencecityFebruary 20, 2020 Read More
Publications of the Week Broadly Neutralizing Antibodies for HIV PreventionKaruna, S.T., & Corey, L. | February 13, 2020In the last decade, over a dozen potent broadly neutralizing antibodies (bnAbs) to several HIV…sciencecityFebruary 13, 2020 Read More
Publications of the Week Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal CulturesSridhar, A., et al. | February 10, 2020The authors used single cell transcriptomic techniques to compare retinal organoids to normal fetal development.…sciencecityFebruary 10, 2020 Read More
Publications of the Week Human DNA-PK Activates a STING-Independent DNA Sensing PathwayBurleigh, K., et al. | February 7, 2020Stimulator of interferon genes (STING) plays a central role in sensing intracellular DNA in mammalian…sciencecityFebruary 7, 2020 Read More