Publications of the Week An Improved Platform for Functional Assessment of Large Protein Libraries in Mammalian CellsMatreyek, K.A., et al. | November 1, 2019Multiplex genetic assays can simultaneously test thousands of genetic variants for a property of interest.…sciencecityNovember 1, 2019 Read More
Publications of the Week Spatiotemporal Expansion of Primary Progenitor Zones in the Developing Human CerebellumHaldipur, P., et al. | October 30, 2019The authors have conducted the first-ever histological and molecular analyses of the developing human cerebellum,…sciencecityOctober 30, 2019 Read More
Publications of the Week Adaptive Archaic Introgression of Copy Number Variants and the Discovery of Previously Unknown Human GenesHsieh, P., et al. | October 28, 2019The authors provide some of the first evidence that large copy-number changes that originated in…sciencecityOctober 28, 2019 Read More
Publications of the Week Treg Cells Maintain Selective Access to IL-2 and Immune Homeostasis Despite Substantially Reduced CD25 FunctionHayes, E.T., et al. | October 25, 2019The cytokine IL-2 is a critical regulator of immune homeostasis The authors found that, despite…sciencecityOctober 25, 2019 Read More
Publications of the Week Spliceosomal Disruption of the Non-Canonical BAF Complex in CancerInoue, D., et al. | October 23, 2019SF3B1 is the most commonly mutated RNA splicing factor in cancer1,2,3,4, but the mechanisms by…sciencecityOctober 23, 2019 Read More
Publications of the Week Expansion of Primitive Human Hematopoietic Stem Cells by Culture in a Zwitterionic HydrogelBai, T, et al. | October 21, 2019The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to…sciencecityOctober 21, 2019 Read More
Publications of the Week Interplay of Disordered and Ordered Regions of a Human Small Heat Shock Protein Yields an Ensemble of ‘Quasi-Ordered’ StatesClouser, A.F., et al. | October 17, 2019Up to 40% of the human proteome, including human small heat shock proteins (sHSPs) and…sciencecityOctober 17, 2019 Read More
Publications of the Week Constitutive XBP-1s-Mediated Activation of the Endoplasmic Reticulum Unfolded Protein Response Protects against Pathological TauWaldherr, S.M., et al. | October 15, 2019To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein. To identify…sciencecityOctober 15, 2019 Read More
Publications of the Week N6-Methyladenosine mRNA Marking Promotes Selective Translation of Regulons Required for Human ErythropoiesisKuppers, D.A., et al. | October 11, 2019Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To…sciencecityOctober 11, 2019 Read More
Publications of the Week γ-Secretase Inhibition Increases Efficacy of BCMA-Specific Chimeric Antigen Receptor T Cells in Multiple MyelomaPont, M., et al. | October 9, 2019B cell maturation antigen (BCMA) is a validated target for chimeric antigen receptor (CAR) T…sciencecityOctober 9, 2019 Read More