Publications of the Week The CXCL12-CXCR4/CXCR7 Axis as a Mechanism of Immune Resistance in Gastrointestinal Malignancies Daniel, S.K., et al. | January 9, 2020 Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal solid tumors, but…sciencecityJanuary 9, 2020 Read More
Publications of the Week Subcellular Drug Targeting Illuminates Local Kinase Action Bucko, P.J., et al. | January 8, 2020 Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase…sciencecityJanuary 8, 2020 Read More
Publications of the Week Antibiotic-Induced Microbiome Perturbations Are Associated with Significant Alterations to Colonic Mucosal Immunity in Rhesus Macaques Manuzak, J.A., et al. | December 20, 2019 The authors evaluated the effects of four specific antibiotics in healthy female rhesus macaques. All…sciencecityDecember 20, 2019 Read More
Publications of the Week Preemptive Mitigation of CD19 CAR T-Cell Cytokine Release Syndrome without Attenuation of Antileukemic Efficacy Gardner, R.A., et al. | December 19, 2019 Immunotherapy with the adoptive transfer of T cells redirected with CD19-specific chimeric antigen receptors (CARs)…sciencecityDecember 19, 2019 Read More
Publications of the Week Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization Parks, K.R., et al. | December 12, 2019 The authors report on a two-step immunization scheme that leads to the maturation of VRC01-like…sciencecityDecember 12, 2019 Read More
Publications of the Week Durable Preservation of Antiviral Antibodies After CD19-Directed Chimeric Antigen Receptor T-Cell Immunotherapy Hill, J.A., et al. | December 9, 2019 The long-term effects of CD19-targeted chimeric antigen receptor–modified T-cell immunotherapy (CD19-CARTx) for B-cell malignancies on…sciencecityDecember 9, 2019 Read More
Publications of the Week A High-Resolution Landscape of Mutations in the BCL6 Super-Enhancer in Normal Human B Cells Shen, J.C., et al. | December 4, 2019 We used duplex sequencing to detect low-frequency mutations in the BCL6 super-enhancer locus in normal human B…sciencecityDecember 4, 2019 Read More
Publications of the Week RNA-Binding Protein Isoforms ZAP-S and ZAP-L Have Distinct Antiviral and Immune Resolution Functions Schwerk, J., et al. | December 2, 2019 Robust inflammatory responses are essential to control microbial infections. At the same time, it is…sciencecityDecember 2, 2019 Read More
Publications of the Week Macrophage-Associated Wound Healing Contributes to African Green Monkey SIV Pathogenesis Control Barrenas, F., et al. | November 29, 2019 The authors applied functional genomics and bioinformatics analyses to a model of acute HIV infection.…sciencecityNovember 29, 2019 Read More
Publications of the Week DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression Resnick, R., et al. | November 27, 2019 When DUX4 is expressed in the early embryo, there is a significant epigenetic reprogramming that…sciencecityNovember 27, 2019 Read More