Publications of the Week Proteomic Analysis Uncovers Multi-Protein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus Pyle, L., et al. | November 14, 2024 The onset of diabetic kidney disease (DKD) in youth with type 2 diabetes mellitus often…karnottNovember 14, 2024 Read More
Publications of the Week An IL-2 Mutein Increases Regulatory T Cell Suppression of Dendritic Cells via IL-10 and CTLA-4 to Promote T Cell Anergy Jamison, B., et al. | November 7, 2024 Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3+ regulatory T (TR) cells are…karnottNovember 7, 2024 Read More
Publications of the Week Label-Free, Real-Time Monitoring of Cytochrome C Drug Responses in Microdissected Tumor Biopsies with a Multi-Well Aptasensor Platform Nguyen, T., et al. | October 28, 2024 Functional assays on intact tumor biopsies can complement genomics-based approaches for precision oncology, drug testing,…karnottOctober 28, 2024 Read More
Publications of the Week Integrated Multimodal Cell Atlas of Alzheimer’s Disease Gabitto, M., et al. | October 22, 2024 Alzheimer’s disease (AD) is the leading cause of dementia in older adults. Although AD progression…karnottOctober 22, 2024 Read More
Publications of the Week Viral Gene Drive Spread During Herpes Simplex Virus 1 Infection in Mice Walter, M., et al. | October 18, 2024 Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely…karnottOctober 18, 2024 Read More
Publications of the Week Host Cell Glycosylation Selects for Infection with CCR5- Versus CXCR4-Tropic HIV-1 Itell, H., et al. | October 11, 2024 Human immunodeficiency virus type 1 (HIV-1) infection involves a selection bottleneck that leads to transmission…karnottOctober 11, 2024 Read More
Publications of the Week Progression to Type 1 Diabetes in the DPT-1 and TN07 Clinical Trials Is Critically Associated with Specific Residues in HLA-DQA1-B1 Heterodimers Zhao, L., et al. | October 4, 2024 The aim of this work was to explore molecular amino acids (AAs) and related structures…karnottOctober 4, 2024 Read More
Publications of the Week Deep Mutational Scanning of CYP2C19 in Human Cells Reveals a Substrate Specificity-Abundance Tradeoff Get Access Arrow Boyle, G., et al. | September 27, 2024 The Cytochrome P450s (CYPs) enzyme family metabolizes ∼80% of small molecule drugs. Variants in CYPs…karnottSeptember 27, 2024 Read More
Publications of the Week Elevated Apolipoprotein C3 Augments Diabetic Kidney Disease and Associated Atherosclerosis in Type 2 Diabetes Cervantes, J., et al. | September 18, 2024 Diabetes increases the risk of both cardiovascular disease and kidney disease. Notably, most of the…karnottSeptember 18, 2024 Read More
Publications of the Week Origin of Biogeographically Distinct Ecotypes During Laboratory Evolution Valenzuela, J., et al. | September 12, 2024 Resource partitioning is central to the incredible productivity of microbial communities, including gigatons in annual…karnottSeptember 12, 2024 Read More