Publications of the Week Mutations in Nucleotide Metabolism Genes Bypass Proteasome Defects in png-1/NGLY1-Deficient Caenorhabditis elegans Yanagi, K., et al. | July 29, 2024 The conserved SKN-1A/Nrf1 transcription factor regulates the expression of proteasome subunit genes and is essential…karnottJuly 29, 2024 Read More
Publications of the Week Symbolic Recording of Signalling and Cis-Regulatory Element Activity to DNA Chen, W., et al. | July 24, 2024 Measurements of gene expression or signal transduction activity are conventionally performed using methods that require…karnottJuly 24, 2024 Read More
Publications of the Week Split Intein-Mediated Protein Trans-splicing to Express Large Dystrophins Tasfaout, H., et al. | July 23, 2024 Gene replacement using adeno-associated virus (AAV) vectors is a promising therapeutic approach for many diseases1,2.…karnottJuly 23, 2024 Read More
Publications of the Week Structural and Genetic Diversity in the Secreted Mucins MUC5AC and MUC5B Plender, E., et al. | July 17, 2024 The secreted mucins MUC5AC and MUC5B are large glycoproteins that play critical defensive roles in…karnottJuly 17, 2024 Read More
Publications of the Week Long-Term Engraftment and Maturation of Autologous iPSC-Derived Cardiomyocytes in Two Rhesus Macaques Lin, Y., et al. | July 15, 2024 Cellular therapies with cardiomyocytes produced from induced pluripotent stem cells (iPSC-CMs) offer a potential route…karnottJuly 15, 2024 Read More
Publications of the Week Gene Regulatory Network Topology Governs Resistance and Treatment Escape in Glioma Stem-Like Cells | July 10, 2024 Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced…karnottJuly 10, 2024 Read More
Publications of the Week Lupus IgA1 Autoantibodies Synergize with IgG to Enhance Plasmacytoid Dendritic Cell Responses to RNA-Containing Immune Complexes | July 9, 2024 Autoantibodies to nuclear antigens contribute to pathology in systemic lupus erythematosus (SLE). However, it is…karnottJuly 9, 2024 Read More
Publications of the Week Spike Deep Mutational Scanning Helps Predict Success of SARS-CoV-2 Clades Dadonaite, B., et al. | July 3, 2024 SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion1 and affect other…karnottJuly 3, 2024 Read More
Publications of the Week Microbial Community-Scale Metabolic Modelling Predicts Personalized Short-Chain Fatty Acid Production Profiles in the Human Gut Quinn-Bohmann, N., et al. | June 27, 2024 Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host…karnottJune 27, 2024 Read More
Publications of the Week High-Throughput Single-Cell Transcriptomics of Bacteria Using Combinatorial Barcoding Gaisser, K., et al. | June 26, 2024 Microbial split-pool ligation transcriptomics (microSPLiT) is a high-throughput single-cell RNA sequencing method for bacteria. With…karnottJune 26, 2024 Read More