Publications of the Week Coordinated Mis-Splicing of TMEM14C and ABCB7 Causes Ring Sideroblast Formation in SF3B1-Mutant Myelodysplastic Syndrome Clough, C., et al. | December 14, 2021 SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts, a clonal…dcorriganDecember 14, 2021 Read More
Publications of the Week Information Flow in the Spatiotemporal Organization of Immune Responses Huang, J., Lyons-Cohen, M., and Gerner, M. | December 10, 2021 Immune responses must be rapid, tightly orchestrated, and tailored to the encountered stimulus. Lymphatic vessels…dcorriganDecember 10, 2021 Read More
Publications of the Week Discrete Regulatory Modules Instruct Hematopoietic Lineage Commitment and Differentiation Georgolopoulos, G., et al. | December 9, 2021 Lineage commitment and differentiation is driven by the concerted action of master transcriptional regulators at…dcorriganDecember 9, 2021 Read More
Publications of the Week Drug Delivery to the Central Nervous System Nance, E., et al. | December 8, 2021 Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug development remains…dcorriganDecember 8, 2021 Read More
Publications of the Week Multiomic Characterization of Oncogenic Signaling Mediated by Wild-Type and Mutant RIT1 Lo, A., et al. | December 3, 2021 Aberrant activation of the RAS family of guanosine triphosphatases (GTPases) is prevalent in lung adenocarcinoma,…dcorriganDecember 3, 2021 Read More
Publications of the Week De Novo Protein Design by Deep Network Hallucination Anishchenko, I., et al. | December 2, 2021 There has been considerable recent progress in protein structure prediction using deep neural networks to…dcorriganDecember 2, 2021 Read More
Publications of the Week Mucosal Tissue Regulatory T Cells Are Integral in Balancing Immunity and Tolerance at Portals of Antigen Entry Traxinger, B. R., Richert-Spuhler, L. E., and Lund, J. M. | December 1, 2021 Foxp3+ regulatory T cells (Tregs) are a subset of CD4+ T cells that exert suppressive…dcorriganDecember 1, 2021 Read More
Publications of the Week Directional Reorientation of Migrating Neutrophils Is Limited by Suppression of Receptor Input Signaling at the Cell Rear through Myosin II Activity Hadjitheodorou, A., et al. | November 26, 2021 To migrate efficiently to target locations, cells must integrate receptor inputs while maintaining polarity: a…dcorriganNovember 26, 2021 Read More
Publications of the Week Molecular Basis of Immune Evasion by the Delta and Kappa SARS-CoV-2 Variants Mccallum, M., et al. | November 25, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including…dcorriganNovember 25, 2021 Read More
Publications of the Week Cross-Validation of SARS-CoV-2 Responses in Kidney Organoids and Clinical Populations Helms, L., et al. | November 23, 2021 Using organoids, the authors discovered that SARS-CoV-2 has an exquisite ability to infect a specific…dcorriganNovember 23, 2021 Read More