Publications of the Week Engineering Heart MorphogenesisMandrycky, C., et al. | August 3, 2020There is high potential for current technologies to be used to recapitulate heart development in vitro by…emcguinnAugust 3, 2020 Read More
Publications of the Week Increasing Fatty Acid Oxidation Prevents High Fat Diet Induced Cardiomyopathy through Regulating Parkin Mediated MitophagyShao, D., et al. | July 31, 2020The Tian Laboratory focuses on the roles of cell metabolism and mitochondrial function in the pathogenesis of…emcguinnJuly 31, 2020 Read More
Publications of the Week The NK Cell–Cancer Cycle: Advances and New Challenges in NK Cell–Based ImmunotherapiesBald, T., et al. | July 30, 2020Natural killer (NK) cells belong to the innate immune system and contribute to protecting the…emcguinnJuly 30, 2020 Read More
Publications of the Week Assembly of the Threespine Stickleback Y Chromosome Reveals Convergent Signatures of Sex Chromosome EvolutionPeichel, C., et al. | July 24, 2020Heteromorphic sex chromosomes have evolved repeatedly across diverse species. Suppression of recombination between X and…emcguinnJuly 24, 2020 Read More
Publications of the Week Robust Expansion of HIV CAR T Cells following Antigen Boosting in ART-Suppressed Nonhuman PrimatesRust, B., et al. | July 22, 2020The authors observed that virus-specific CAR T-cells were less functional in vivo, relative to CAR T-cells…emcguinnJuly 22, 2020 Read More
Publications of the Week Small-Molecule Sensitization of RecBCD Helicase–Nuclease to a Chi Hotspot-Activated StateKarabulut, A., et al. | July 17, 2020We study a small molecule (NSAC1003) that one of our collaborators (Ryan Cirz) at Achaogen,…emcguinnJuly 17, 2020 Read More
Publications of the Week Dissemination of RasV12-Transformed Cells Requires the Mechanosensitive Channel PiezoLee, J., et al. | July 17, 2020Dissemination of transformed cells is a key process in metastasis. Despite its importance, how transformed…emcguinnJuly 17, 2020 Read More
Publications of the Week KSHV Requires vCyclin to Overcome Replicative Senescence in Primary Human Lymphatic Endothelial CellsDiMaio, T., et al. | July 10, 2020Kaposi’s Sarcoma Herpesvirus (KSHV) is present in the main tumor cells of Kaposi’s Sarcoma (KS),…emcguinnJuly 10, 2020 Read More
Publications of the Week Cytosolic Delivery of Proteins by Cholesterol TaggingTai, W., et al. | July 7, 2020Protein-based imaging agents and therapeutics are superior in structural and functional diversity compared to small…eabramovichJuly 7, 2020 Read More
Publications of the Week Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in ObesityHan, CY et al. | July 3, 2020Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their…eabramovichJuly 3, 2020 Read More