Publications of the Week Chromatin Accessibility Dynamics and Single Cell RNA-Seq Reveal New Regulators of Regeneration in Neural ProgenitorsWills, A. E., et al. | May 4, 2020Vertebrate appendage regeneration requires precisely coordinated remodeling of the transcriptional landscape to enable the growth…emcguinnMay 4, 2020 Read More
Publications of the Week A TfR-Binding Cystine-Dense Peptide Promotes Blood–Brain Barrier Penetration of Bioactive MoleculesOlson, J.M., et al. | April 30, 2020Transferrin receptor (TfR) binding entities can be used as vehicles for CNS drug delivery, however…eabramovichApril 30, 2020 Read More
Publications of the Week Coevolution of Host-Plasmid Pairs Facilitates the Emergence of Novel Multidrug ResistanceKerr, B., et al. | April 24, 2020Multidrug resistance (MDR) of pathogens is an ongoing public health crisis exacerbated by the horizontal…emcguinnApril 24, 2020 Read More
Publications of the Week RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosaDandekar, A.A., et al. | April 22, 2020The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection in cystic fibrosis…emcguinnApril 22, 2020 Read More
Publications of the Week Intermediate Progenitors Support Migration of Neural Stem Cells into Dentate Gyrus Outer Neurogenic NichesNelson, B.R., et al. | April 16, 2020The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs)…emcguinnApril 16, 2020 Read More
Publications of the Week Effective CRISPRa-Mediated Control of Gene Expression in Bacteria Must Overcome Strict Target Site RequirementsFontana, J., et al. | April 14, 2020The authors describe several features of bacterial genes that impose stringent requirements on CRISPR-Cas tools…eabramovichApril 14, 2020 Read More
Publications of the Week Resolving the Synaptic versus Developmental Dichotomy of Autism Risk GenesHeavner, W.H., & Smith, S.E.P. | April 10, 2020Autism Spectrum Disorder (ASD) risk genes are often described as either developmental or synaptic. However,…sciencecityApril 10, 2020 Read More
Publications of the Week Phenomics-Based Quantification of CRISPR-Induced Mosaicism in ZebrafishWatson, C.J., et al. | April 8, 2020This manuscript provides validation of an approach to rapidly screen zebrafish using first-generation CRISPR-edited mutants…sciencecityApril 8, 2020 Read More
Publications of the Week Dimensionality Reduction by UMAP to Visualize Physical and Genetic InteractionsDorrity, M.W., et al. | April 3, 2020Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the…sciencecityApril 3, 2020 Read More
Publications of the Week RecV Recombinase System for In Vivo Targeted Optogenomic Modifications of Single Cells or Cell PopulationsYao, S., et al. | April 1, 2020Brain circuits comprise vast numbers of interconnected neurons with diverse molecular, anatomical and physiological properties.…sciencecityApril 1, 2020 Read More