Publications of the Week Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in the In Vitro Respiratory Network Burgraff, N. J., et al. | November 4, 2021 Death from opioid overdose is typically caused by opioid-induced respiratory depression (OIRD). A particularly dangerous…dcorriganNovember 4, 2021 Read More
Publications of the Week Metabolic Regulation by PD-1 Signaling Promotes Long-Lived Quiescent CD8 T Cell Memory in Mice Kalia, V., et al. | November 1, 2021 Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1) axis…dcorriganNovember 1, 2021 Read More
Publications of the Week Transcriptional and Functional Divergence in Lateral Hypothalamic Glutamate Neurons Projecting to the Lateral Habenula and Ventral Tegmental Area Neuron | October 29, 2021 The lateral hypothalamic area (LHA) regulates feeding- and reward-related behavior, but because of its molecular…dcorriganOctober 29, 2021 Read More
Publications of the Week The Novel Anti-CRISPR AcrIIA22 Relieves DNA Torsion in Target Plasmids and Impairs SpyCas9 Activity Forsberg, K. J., et al. | October 28, 2021 To overcome CRISPR-Cas defense systems, many phages and mobile genetic elements (MGEs) encode CRISPR-Cas inhibitors…dcorriganOctober 28, 2021 Read More
Publications of the Week Laminar Distribution and Arbor Density of Two Functional Classes of Thalamic Inputs to Primary Visual Cortex Zhuang, J., et al. | October 26, 2021 By combining physiological and anatomical techniques, the authors traced and reconstructed complete axon arbors and…dcorriganOctober 26, 2021 Read More
Publications of the Week An Endogenous Opioid Circuit Determines State-Dependent Reward Consumption Castro, D. C., et al. | October 21, 2021 The authors pin down a major biological mechanism through which opioids act to potentiate motivated…dcorriganOctober 21, 2021 Read More
Publications of the Week Precise Genomic Deletions Using Paired Prime Editing Junhong, C., et al. | October 20, 2021 Recently, “prime editing”, a new method that builds on CRISPR, improved the precision of genome…dcorriganOctober 20, 2021 Read More
Publications of the Week Attenuation of Apoptotic Cell Detection Triggers Thymic Regeneration after Damage Kinsella, S., et al. | October 15, 2021 The authors reveal a complicated molecular switch that orchestrates the regenerative response. Specifically, what they…dcorriganOctober 15, 2021 Read More
Publications of the Week Adaptations in Hippo-Yap Signaling and Myofibroblast Fate Underlie Scar-Free Ear Appendage Wound Healing in Spiny Mice Brewer, C. M., et al. | October 14, 2021 Most mammalian species exhibit scar-free wound repair during fetal or early postnatal development. However, this…dcorriganOctober 14, 2021 Read More
Publications of the Week Anticoagulation Targeting Membrane-Bound Anionic Phospholipids Improved Outcomes of Traumatic Brain Injury in Mice Dong, X., et al. | October 12, 2021 Severe traumatic brain injury (TBI) often causes an acute systemic hypercoagulable state that rapidly develops…dcorriganOctober 12, 2021 Read More