Publications of the Week Discovery of Synthetic Lethal and Tumor Suppressor Paralog Pairs in the Human Genome Parrish, P. C. R., et al. | September 10, 2021 For the past decade, scientists have performed genome-wide screens to identify important cancer genes –…dcorriganSeptember 10, 2021 Read More
Publications of the Week Antibodies to EGF Receptor Family Members Can Upregulate Tumor Immunity Min, D., et al. | September 6, 2021 Immunologic mechanisms influence how a cancer patient responds to therapy. Monoclonal antibodies (mAbs) to the…dcorriganSeptember 6, 2021 Read More
Publications of the Week Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia Le, Q., et al. | September 3, 2021 A significant barrier to effective immunotherapy in AML is the shared immunophenotype between AML and…dcorriganSeptember 3, 2021 Read More
Publications of the Week Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants Tchesnokova, V., et al. | August 31, 2021 My lab is working in two major directions – molecular evolution of human pathogens and…dcorriganAugust 31, 2021 Read More
Publications of the Week Comparative Analysis of TCR and CAR Signaling Informs CAR Designs with Superior Antigen Sensitivity and In Vivo Function Salter, A. I., et al. | August 30, 2021 Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas, leukemias, and multiple…dcorriganAugust 30, 2021 Read More
Publications of the Week The Landscape of Alternative Polyadenylation in Single Cells of the Developing Mouse Embryo Agarwal, V., et al. | August 27, 2021 3′ untranslated regions (3′ UTRs) post-transcriptionally regulate mRNA stability, localization, and translation rate. While 3′-UTR…dcorriganAugust 27, 2021 Read More
Publications of the Week A Therapeutic Cancer Vaccine Delivers Antigens and Adjuvants to Lymphoid Tissues Using Genetically Modified T Cells Veatch, J.R., et al. | August 26, 2021 The authors showed that Tvax works by delivering antigens to lymphoid organs throughout the body…dcorriganAugust 26, 2021 Read More
Publications of the Week Endomembrane Targeting of Human OAS1 p46 Augments Antiviral Activity Soveg, F., et al. | August 23, 2021 Lead authors Frank Soveg and Johannes Schwerk identified a membrane-targeted gene, OAS1 p46, with strong…dcorriganAugust 23, 2021 Read More
Publications of the Week The Redox-Responsive Transcriptional Regulator Rex Represses Fermentative Metabolism and Is Required for Listeria monocytogenes Pathogenesis Halsey, C., et al. | August 20, 2021 In this work, we characterized the role of the redox-responsive transcriptional regulator Rex in Listeria…dcorriganAugust 20, 2021 Read More
Publications of the Week Massively Parallel Characterization of CYP2C9 Variant Enzyme Activity and Abundance Amorosi, C., et al. | August 20, 2021 Scientists only have accurate dosage advice for a small number of the most well-studied genetic…dcorriganAugust 20, 2021 Read More