Publications of the Week Accurate Prediction of Protein Structures and Interactions Using a Three-Track Neural Network Baek, M., et al. | July 22, 2021 DeepMind presented remarkably accurate predictions at the recent CASP14 protein structure prediction assessment conference. We…kchenJuly 22, 2021 Read More
Publications of the Week Multiplexed Functional Genomic Analysis of 5′ Untranslated Region Mutations across the Spectrum of Prostate Cancer Lim, Y., et al. | July 14, 2021 The functional consequences of genetic variants within 5’ untranslated regions (UTRs) on a genome-wide scale…kchenJuly 14, 2021 Read More
Publications of the Week SARS-CoV-2 Immune Evasion by the B.1.427/B.1.429 Variant of Concern McCallum, M., et al. | July 12, 2021 A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), originally detected in California, carries spike…kchenJuly 12, 2021 Read More
Publications of the Week Activated Interleukin-7 Receptor Signaling Drives B-Cell Acute Lymphoblastic Leukemia in Mice Thomas, K. R., et al. | July 7, 2021 One key focus within our lab is to better understand signaling events that alter lymphocyte…kchenJuly 7, 2021 Read More
Publications of the Week Resolution of Tissue Signatures of Therapy Response in Patients with Recurrent GBM Treated with Neoadjuvant Anti-PD1 Lu, Y., et al. | July 6, 2021 The response of patients with recurrent glioblastoma multiforme to neoadjuvant immune checkpoint blockade has been…kchenJuly 6, 2021 Read More
Publications of the Week Pharmacologic Modulation of RNA Splicing Enhances Anti-Tumor Immunity Lu, S. X., et al. | July 5, 2021 Although mutations in DNA are the best-studied source of neoantigens that determine response to immune…kchenJuly 5, 2021 Read More
Publications of the Week Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury dos Santos, C. C., et al. | June 29, 2021 Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced lung injury in pre-clinical models, the…kchenJune 29, 2021 Read More
Publications of the Week Monocyte Metabolic Transcriptional Programs Associate with Resistance to Tuberculin Skin Test/Interferon-γ Release Assay Conversion Simmons, J. D., et al. | June 29, 2021 After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire latent Mtb infection (LTBI) defined…kchenJune 29, 2021 Read More
Publications of the Week CMV Exposure Drives Long-Term CD57+ CD4 Memory T Cell Inflation Following Allogeneic Stem Cell Transplant Yeh, A. C., et al. | June 25, 2021 Donor and recipient cytomegalovirus (CMV) serostatus correlate with transplant related mortality that is associated with…kchenJune 25, 2021 Read More
Publications of the Week The PI3K/mTOR Inhibitor Gedatolisib Eliminates Dormant Breast Cancer Cells in Organotypic Culture, but Fails to Prevent Metastasis in Preclinical Settings Shor, R. E., et al. | June 23, 2021 The authors study breast cancer metastasis and the biology of disseminated tumor cells (DTCs) and…kchenJune 23, 2021 Read More