Publications of the Week Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans Diener, C., et al. | September 17, 2021 Some people have a harder time losing weight than others. The current study, along with…dcorriganSeptember 17, 2021 Read More
Publications of the Week Integrating T Cell Receptor Sequences and Transcriptional Profiles by Clonotype Neighbor Graph Analysis (CoNGA) Schattgen, S. A., et al. | September 16, 2021 Links between T cell clonotypes, as defined by T cell receptor (TCR) sequences, and phenotype,…dcorriganSeptember 16, 2021 Read More
Publications of the Week Integrated Analysis of Plasma and Single Immune Cells Uncovers Metabolic Changes in Individuals with COVID-19 Lee., J.W., et al. | September 14, 2021 A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome…dcorriganSeptember 14, 2021 Read More
Publications of the Week Discovery of Synthetic Lethal and Tumor Suppressor Paralog Pairs in the Human Genome Parrish, P. C. R., et al. | September 10, 2021 For the past decade, scientists have performed genome-wide screens to identify important cancer genes –…dcorriganSeptember 10, 2021 Read More
Publications of the Week Antibodies to EGF Receptor Family Members Can Upregulate Tumor Immunity Min, D., et al. | September 6, 2021 Immunologic mechanisms influence how a cancer patient responds to therapy. Monoclonal antibodies (mAbs) to the…dcorriganSeptember 6, 2021 Read More
Publications of the Week Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia Le, Q., et al. | September 3, 2021 A significant barrier to effective immunotherapy in AML is the shared immunophenotype between AML and…dcorriganSeptember 3, 2021 Read More
Publications of the Week Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants Tchesnokova, V., et al. | August 31, 2021 My lab is working in two major directions – molecular evolution of human pathogens and…dcorriganAugust 31, 2021 Read More
Publications of the Week Comparative Analysis of TCR and CAR Signaling Informs CAR Designs with Superior Antigen Sensitivity and In Vivo Function Salter, A. I., et al. | August 30, 2021 Chimeric antigen receptor (CAR)–modified T cell therapy is effective in treating lymphomas, leukemias, and multiple…dcorriganAugust 30, 2021 Read More
Publications of the Week The Landscape of Alternative Polyadenylation in Single Cells of the Developing Mouse Embryo Agarwal, V., et al. | August 27, 2021 3′ untranslated regions (3′ UTRs) post-transcriptionally regulate mRNA stability, localization, and translation rate. While 3′-UTR…dcorriganAugust 27, 2021 Read More
Publications of the Week A Therapeutic Cancer Vaccine Delivers Antigens and Adjuvants to Lymphoid Tissues Using Genetically Modified T Cells Veatch, J.R., et al. | August 26, 2021 The authors showed that Tvax works by delivering antigens to lymphoid organs throughout the body…dcorriganAugust 26, 2021 Read More