Publications of the Week The PI3K/mTOR Inhibitor Gedatolisib Eliminates Dormant Breast Cancer Cells in Organotypic Culture, but Fails to Prevent Metastasis in Preclinical Settings Shor, R. E., et al. | June 23, 2021 The authors study breast cancer metastasis and the biology of disseminated tumor cells (DTCs) and…kchenJune 23, 2021 Read More
Publications of the Week Tumors Overcome the Action of the Wasting Factor ImpL2 by Locally Elevating Wnt/Wingless Lee, J., et al. | June 16, 2021 My lab uses Drosophila melanogaster as a model to study cancer-related processes, such as cachexia…kchenJune 16, 2021 Read More
Publications of the Week Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic Transmission Ciccocioppo, R. et al. | June 15, 2021 Background: About 5 million people die from diseases related to nicotine addiction and tobacco use…kchenJune 15, 2021 Read More
Publications of the Week Generation of Ordered Protein Assemblies Using Rigid Three-Body Fusion Vulovic, I. et al. | June 10, 2021 Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A long-standing…kchenJune 10, 2021 Read More
Publications of the Week Identification of In Vivo Hox13-Binding Sites Reveals an Essential Locus Controlling Zebrafish Brachyury Expression Ye, Z., et al. | June 8, 2021 My lab studies how the early vertebrate embryo forms using zebrafish as a model system.…kchenJune 8, 2021 Read More
Publications of the Week Live-Attenuated RNA Hybrid Vaccine Technology Provides Single-Dose Protection against Chikungunya Virus Voigt, A. E., at al. | June 7, 2021 We present a live-attenuated RNA hybrid vaccine technology which uses an RNA vaccine delivery vehicle…kchenJune 7, 2021 Read More
Publications of the Week A Taxonomy of Transcriptomic Cell Types across the Isocortex and Hippocampal Formation Yao, Z., et al. | June 2, 2021 Our team at the Allen Institute for Brain Science studies cell type diversity in the…kchenJune 2, 2021 Read More
Publications of the Week mRNA Translation Is a Therapeutic Vulnerability Necessary for Bladder Epithelial Transformation Jana, S., et al. | June 1, 2021 Our laboratory studies the process of mRNA translation in normal cell physiology and disease. We…kchenJune 1, 2021 Read More
Publications of the Week Selective Androgen Receptor Modulators Activate the Canonical Prostate Cancer Androgen Receptor Program and Repress Cancer Growth Nyquist, D. M., et al. | May 28, 2021 Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate…kchenMay 28, 2021 Read More
Publications of the Week A Photoswitchable GPCR-Based Opsin for Presynaptic Inhibition Copits, A. B., et al. | May 26, 2021 The authors focus on neuromodulatory processing in the brain, as it relates to effective behavior.…kchenMay 26, 2021 Read More