Publications of the Week Donor T Cell STAT3 Deficiency Enables Tissue PD-L1–Dependent Prevention of Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia ActivityLi, Q., et al. | August 3, 2023STAT3 deficiency (STAT3–/–) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on…pthomsonAugust 3, 2023 Read More
Publications of the Week Multi-Level Functional Genomics Reveals Molecular and Cellular Oncogenicity of Patient-Based 3′ Untranslated Region MutationsHsieh, A., et al. | July 31, 20233′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic…pthomsonJuly 31, 2023 Read More
Publications of the Week Intestinal Microbiota Controls Graft-Versus-Host Disease Independent of Donor-Host Genetic DisparityHill, G., et al. | July 27, 2023Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic stem cell transplantation (SCT), and…pthomsonJuly 27, 2023 Read More
Publications of the Week Hypoxia-Induced Mitochondrial Stress GranulesCrowder, C. M., et al. | July 21, 2023Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic…pthomsonJuly 21, 2023 Read More
Publications of the Week Factors Associated with Recurrent Appendicitis After Successful Treatment with AntibioticsFlum, D., et al. | July 19, 2023As more patients with appendicitis are treated with antibiotics, factors associated with recurrence may help…pthomsonJuly 19, 2023 Read More
Publications of the Week De Novo Design of Protein Structure and Function with RFdiffusionBaker, D., et al. | July 14, 2023The authors showed that by fine tuning the RoseTTAFold structure prediction network on protein structure…pthomsonJuly 14, 2023 Read More
Publications of the Week A Human-Specific Motif Facilitates CARD8 Inflammasome Activation After HIV-1 InfectionMitchell, P., et al. | July 12, 2023Inflammasomes are cytosolic innate immune complexes that assemble upon detection of diverse pathogen-associated cues and…pthomsonJuly 12, 2023 Read More
Publications of the Week CD1 and iNKT Cells Mediate Immune Responses Against the GBS Hemolytic Lipid Toxin Induced by a Non-toxic AnalogRajagopal, L., et al. | July 6, 2023Although hemolytic lipids have been discovered from many human pathogens including Group B Streptococcus (GBS),…pthomsonJuly 6, 2023 Read More
Publications of the Week Androgen-Regulated Stromal Complement Component 7 (C7) Suppresses Prostate Cancer GrowthXin, L., et al. | July 5, 2023Investigators show that C7 is specifically expressed by the stromal cells in both mouse and human…pthomsonJuly 5, 2023 Read More
Publications of the Week Nuclear Pore Complexes Mediate Subtelomeric Gene Silencing by Regulating PCNA Levels on ChromatinAitchison, J. D., et al. | June 30, 2023The nuclear pore complex (NPC) physically interacts with chromatin and regulates gene expression. The Saccharomyces cerevisiae…pthomsonJune 30, 2023 Read More