Publications of the Week Modified Manufacturing Process Modulates CD19 CAR T Cell Engraftment Fitness and Leukemia-Free Survival in Pediatric and Young Adult SubjectsCeppi, F., et al. | May 20, 2022T cells modified to express a chimeric-antigen receptor (CAR)targeting CD19 can induce potent and sustained…dcorriganMay 20, 2022 Read More
Publications of the Week A Recombinant Alpha-Like Protein Subunit Vaccine (GBS-NN) Provides Protection in Murine Models of Group B Streptococcus Infection Get Access ArrowBrokaw, A., et al. | May 19, 2022Group B Streptococcus (GBS) transmission during pregnancy causes preterm labor, stillbirths, fetal injury, or neonatal infections.…dcorriganMay 19, 2022 Read More
Publications of the Week Extricating Human Tumor Immune Alterations from Tissue InflammationNature | May 16, 2022The authors compared human tumor tissues to non-malignant, inflamed tissues and observed extensive phenotypic and…dcorriganMay 16, 2022 Read More
Publications of the Week Colorectal Cancer Is Associated with the Presence of Cancer Driver Mutations in Normal ColonMatas, J., et al. | May 13, 2022Although somatic mutations in colorectal cancer are well characterized, little is known about the accumulation…dcorriganMay 13, 2022 Read More
Publications of the Week Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of Tgfbr2 in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor DysfunctionLee, C. Y., et al. | May 12, 2022The authors showed that TGF-β signaling in smooth muscle cells during embryogenesis and early postnatal…dcorriganMay 12, 2022 Read More
Publications of the Week Development of [211At]astatine-Based Anti-CD123 Radioimmunotherapy for Acute Leukemias and Other CD123+ MalignanciesLaszlo, G. S., et al. | May 6, 2022Read the Publication This week we profile a recent publication in Leukemia from Dr. George…dcorriganMay 6, 2022 Read More
Publications of the Week Simultaneous Brain Cell Type and Lineage Determined by scRNA-Seq Reveals Stereotyped Cortical DevelopmentAnderson, D. J., et al. | May 2, 2022The authors show that a commonly occurring type of somatic mutation, loss of heterozygosity (LOH),…dcorriganMay 2, 2022 Read More
Publications of the Week Autocrine and Paracrine IL-2 Signals Collaborate to Regulate Distinct Phases of CD8 T Cell MemoryToumi, R., et al. | April 28, 2022Differential interleukin-2 (IL-2) signaling and production are associated with disparate effector and memory fates. Whether…dcorriganApril 28, 2022 Read More
Publications of the Week Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental DisordersHaldipur, P., Millen, K. J., and Aldinger, K. A. | April 28, 2022Developmental abnormalities of the cerebellum are among the most recognized structural brain malformations in human…dcorriganApril 28, 2022 Read More
Publications of the Week Neoantigen-Specific CD4+ T Cells in Human Melanoma Have Diverse Differentiation States and Correlate with CD8+ T Cell, Macrophage, and B Cell FunctionVeatch, J., et al. | April 22, 2022The authors show that only a subset of the CD4+ T cells that are present…dcorriganApril 22, 2022 Read More