Publications of the Week Inter- and Intra-Tumor Heterogeneity of Metastatic Prostate Cancer Determined by Digital Spatial Gene Expression Profiling Brady, L., et al. | March 10, 2021 The Nelson lab’s primary research focus is on prostate cancer, the second most common malignancy…kchenMarch 10, 2021 Read More
Publications of the Week Pseudomonas aeruginosa Aggregates in Cystic Fibrosis Sputum Produce Exopolysaccharides That Likely Impede Current Therapies Jennings, L. K., et al. | March 9, 2021 In cystic fibrosis (CF) airways, Pseudomonas aeruginosa forms cellular aggregates called biofilms that are thought to contribute…kchenMarch 9, 2021 Read More
Publications of the Week Mechanical Competition Triggered by Innate Immune Signaling Drives the Collective Extrusion of Bacterially Infected Epithelial Cells Bastounis, E. E., et al. | March 8, 2021 Intracellular pathogens alter their host cells' mechanics to promote dissemination through tissues. Conversely, host cells…kchenMarch 8, 2021 Read More
Publications of the Week Compartmentalization of Phosphatidylinositol 4,5-Bisphosphate Metabolism Into Plasma Membrane Liquid-Ordered/Raft Domains Myeong, J., et al. | March 5, 2021 Lipids of bilayer membranes can segregate laterally into distinct liquid phases of different composition called…kchenMarch 5, 2021 Read More
Publications of the Week Haplotype-Resolved Diverse Human Genomes and Integrated Analysis of Structural Variation Ebert, P., et al. | March 4, 2021 Long-read and strand-specific sequencing technologies together facilitate the de novo assembly of high-quality haplotype-resolved human…kchenMarch 4, 2021 Read More
Publications of the Week Cx43 Phosphorylation Sites Regulate Pancreatic Cancer Metastasis Solan, J.L., et al. | March 4, 2021 The work discussed here highlights our work on gap junctions. Gap junctions are highly organized…kchenMarch 4, 2021 Read More
Publications of the Week Brain Capillary Pericytes Exert a Substantial but Slow Influence on Blood Flow Hartmann, D.A., et al. | February 26, 2021 The research in our lab focuses on the smallest blood vessels that deliver oxygen and…kchenFebruary 26, 2021 Read More
Publications of the Week The Krüppel-Like Factor Cabut Has Cell Cycle Regulatory Properties Similar to E2F1 Zhang, P., et al. | February 24, 2021 Using a gain-of-function screen in Drosophila, we identified the Krüppel-like factor Cabut (Cbt) as a…kchenFebruary 24, 2021 Read More
Publications of the Week Targeting the Membrane-Proximal C2-Set Domain of CD33 for Improved CD33-Directed Immunotherapy Godwin, C.D., et al. | February 22, 2021 There is increasing interest in targeting CD33 in malignant and non-malignant disorders. In acute myeloid…kchenFebruary 22, 2021 Read More
Publications of the Week BRCA1/BARD1 Site-Specific Ubiquitylation of Nucleosomal H2A Is Directed by BARD1 Witus, S.R., et al. | February 19, 2021 Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to breast and…kchenFebruary 19, 2021 Read More