Publications of the Week Suppression of Monosodium Urate Crystal-Induced Inflammation by Inhibiting TGF-β-Activated Kinase 1-Dependent Signaling: Role of the Ubiquitin Proteasome System Singh, A.K., et al. | October 3, 2019 Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1β (IL-1β) signaling. However, the…sciencecityOctober 3, 2019 Read More
Publications of the Week Functional Metagenomics-Guided Discovery of Potent Cas9 Inhibitors in the Human Microbiome Forsberg, K.J., et al. | September 30, 2019 CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use…sciencecitySeptember 30, 2019 Read More
Publications of the Week A Lineage-Resolved Molecular Atlas of C. Elegans Embryogenesis at Single-Cell Resolution Packer, J.S., et al. | September 27, 2019 Single-cell RNA sequencing provides the power to identify the developmental trajectory of an organism. However,…sciencecitySeptember 27, 2019 Read More
Publications of the Week Tissue Chips in Space — Challenges and Opportunities Yeung, C.K., et al. | September 25, 2019 The microgravity environment results in a multitude of physiological changes associated with aging and altered…sciencecitySeptember 25, 2019 Read More
Publications of the Week Cell-Specific Image-Guided Transcriptomics Identifies Complex Injuries Caused by Ischemic Acute Kidney Injury in Mice Miyazaki, T., et al. | September 24, 2019 The highly heterogeneous nature of the kidney’s tubular epithelium has made it challenging to identify…sciencecitySeptember 24, 2019 Read More
Publications of the Week Mechanisms of Interplay between Transcription Factors and the 3D Genome Kim, S. & Shendure, J. | September 20, 2019 Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby serve as the protein…sciencecitySeptember 20, 2019 Read More
Publications of the Week Innate Immunity Limits Protective Adaptive Immune Responses against Pre-Erythrocytic Malaria Parasites Minkah, N.K., et al. | September 19, 2019 The authors examined malaria vaccine efficacy in immunized mice in the presence or absence of…sciencecitySeptember 19, 2019 Read More
Publications of the Week A Pooled Single-Cell Genetic Screen Identifies Regulatory Checkpoints in the Continuum of the Epithelial-to-Mesenchymal Transition McFaline-Figueroa, J., et al. | September 17, 2019 EMT is fundamental to normal development and has been implicated in disease as a mechanism…sciencecitySeptember 17, 2019 Read More
Publications of the Week Conserved Cell Types with Divergent Features in Human Versus Mouse Cortex Hodge, R.D., et al. | September 12, 2019 Using single nucleus transcriptomics, the authors showed that there are many different molecularly distinct cell…sciencecitySeptember 12, 2019 Read More
Publications of the Week RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity Orozco, S.L., et al. | September 10, 2019 The authors have previously found that activation of "necroptosis" is accompanied by the production of…sciencecitySeptember 10, 2019 Read More